TRIM5 SUPPRESSES CROSS-SPECIES TRANSMISSION OF A PRIMATE IMMUNODEFICIENCY VIRUS AND SELECTS FOR EMERGENCE OF RESISTANT VARIANTS IN THE NEW SPECIES.

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.

Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in Integrated Fridge/Freezers humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed macaques.Cellular assays and phylogenetic comparisons indirectly support a role for TRIM5alpha, the prod

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Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity.

Genetic background exerts a strong Brow Stamp modulatory effect on the toxicity of aggregation-prone proteins in conformational diseases.In addition to influencing the misfolding and aggregation behavior of the mutant proteins, polymorphisms in putative modifier genes may affect the molecular processes leading to the disease phenotype.Mutations in

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The Effect of Internal Control Factors on the Accountability of the Auditor at the Inspectirate of Jombang District

Government Regulation Number 60 of 2008 on Government Internal Control System is a manifestation of government commitment in order to improve the performance, transparency and accountability of state finance management and to clarify the role of internal control.This study aims at testing and analyzing the influence of internal control factors to a

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