TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.
Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in Integrated Fridge/Freezers humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed macaques.Cellular assays and phylogenetic comparisons indirectly support a role for TRIM5alpha, the prod